謝堅銘(Hsieh, Chien-Ming) 副教授

Email
cmhsieh@tmu.edu.tw
現   職
新藥研發產業博士學位學程 主任
新藥開發研究中心 副主任
藥物科學學科 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
倫敦國王學院Institute of Pharmaceutical Science 博士
2005/10~2010/03
臺北醫學大學藥學系 碩士
1997/09~1999/06
臺北醫學大學藥學系 學士
1993/09~1997/06

本校學術經歷

任職單位與職稱[起迄時間]
藥物科學學科副教授
2021/02/01~
藥物科學學科助理教授
2017/08/01~2021/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
新藥研發產業博士學位學程主任
2022/08/01 ~
新藥開發研究中心副主任
2021/11/06 ~
臨床基因體學暨蛋白質體學碩士學位學程副教授
2021/11/01 ~

其它經歷

任職單位與職稱[起迄時間]
曼徹斯特大學應用藥物動力學研究中心 Sponsored Research
2019/09/01~2020/08/31
靜宜大學化妝品科學系助理教授
2014/08/01~2017/07/31
開南大學養生與健康行銷學系助理教授
2011/08/01~2014/07/31

專長與研究領域

學門領域
藥學
生醫材料
學術專長
奈米科技
奈米科技
控釋藥劑學
控釋藥劑學
藥(製)劑學
藥(製)劑學
藥效藥力學與藥動學
藥效藥力學與藥動學

論文著作

清冊下載


1. 2023 Bayu Tri Murti ,Yi-June Huang,Athika Darumas Putri,Chuan-Pei Lee,Chien-Ming Hsieh,Shih-Min Wei, Meng-Lin Tsai, Chih-Wei Peng, Po-Kang Yang. Free-standing vertically aligned tin disulfide nanosheets for ultrasensitive aptasensor design toward Alzheimer’s diagnosis applications . Chemical Engineering Journal .2023

2. 2023 Hsieh CM,Yang TL,Putri AD,Chen CT. Application of Design of Experiments in the Development of Self-Microemulsifying Drug Delivery Systems. . Pharmaceuticals .2023 ;(16):283

3. 2022 Wei-Jie Cheng,Shyr-Yi Lin,Kuo-Hsiang Chuang,Michael Chen,Hsiu-O Ho,Ling-Chun Chen, Chien-Ming Hsieh, Ming-Thau Sheu. Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer . International Journal of Nanomedicine .2022 ;(2022):5353-5374

4. 2022 Chien-MingHsieh,Li-Feng Hsu. Investigation of the discriminatory ability of analytes for the bioequivalence assessment of ezetimibe: Parent drug, metabolite, total form, and combination of parent drug and total form . European Journal of Pharmaceutical Sciences .2022

5. 2022 Ting-Lun Yang ,Chien-Ming Hsieh,Ling-Jei Meng,Tsuimin Tsai ,Chin-Tin Chen. Oleic Acid-Based Self Micro-Emulsifying Delivery System for Enhancing Antifungal Activities of Clotrimazole . Pharmaceutics .2022

6. 2022 Chia Ying Lee,Chi-Ting Su,Tsuimin Tsai,Chien-Ming Hsieh, Kuan-Yu Hung,Jeng-Wen Huang, Chin-Tin Chen. Formulation Development of Doxycycline-Loaded Lipid Nanocarriers using Microfluidics by QbD Approach . J Pharm Sci .2022

7. 2021 Ritu Ojha,I-Chung Chen,Chien-Ming Hsieh,Kunal Nepali,Row-Wen Lai,Kai-Cheng Hsu, Tony Eight Lin, Shiow-Lin Pan, Mei-Chuan Chen, Jing-Ping Liou. Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent . Journal of Medicinal Chemistry .2021

8. 2021 Wu MH,Wang W,Chao FC,Hsieh CM,Chen LC,Lin HL, Ho HO, Huang TJ, Sheu MT. One-pot fabrication of sacchachitin for production of TEMPO-oxidized sacchachitin nanofibers (TOSCNFs) utilized as scaffolds to enhance bone regeneration . Carbohydrate Polymers .2021

9. 2021 Lin HL,Cheng WT,Chen LC,Ho HO,Lin SY,Hsieh CM. Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability . International Journal of Nanomedicine .2021 ;(2021):651-665

10. 2021 Chen LC,Lin SY,Sheu MT,Su CH,Lin HL,Hsieh CM. Fabrication and characterization of Rhizochitosan and its incorporation with platelet concentrates to promote wound healing . Carbohydrate Polymers .2021

11. 2021 Nepali K,Hsu TI,Hsieh CM,Lo WL,Lai MJ,Hsu KC. Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma . European Journal of Medicinal Chemistry .2021

12. 2021 Athika Darumas Putri,Pai-Shan Chen, Yu-Lin Su,Jia-Pei Lin,Jing-Ping Liou,Chien-Ming Hsieh. Optimization and Development of Selective Histone Deacetylase Inhibitor (MPT0B291)-Loaded Albumin Nanoparticles for Anticancer Therapy . Pharmaceutics .2021 ;(13):1728-1744

13. 2021 Ling-Chun Chen,Wei-Jie Cheng,Shyr-Yi Lin,Ming-Tse Hung,Ming-Thau Sheu,Hong-Liang Lin, Chien-Ming Hsieh. CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas . Drug Delivery .2021 ;(28):2205-2217

14. 2020 Hsieh CM,Wang W,Chen YH,Wei PS,Liu YH,Sheu MT,Ho HO. A Novel Composite Hydrogel Composed of FormicAcid-Decellularized Pepsin-Soluble ExtracellularMatrix Hydrogel and Sacchachitin Hydrogel as Wound Dressing to Synergistically Accelerate Diabetic Wound Healing. . Pharmaceutics .2020 ;(12):538

15. 2020 Cheng KJ,Hsieh CM,Nepali K,Liou JP. Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye . J Med Chem .2020

16. 2019 Yueh-Chan Lee,Chien-Ming Hsieh,Tsung-Neng Tsai,Da-Peng Yang,Pai-Shan Chen. Ultrasound-assisted synthesis of thermosensitive nanovesicle for direct trap and release of analgesic drugs in biofluid and sewage. . Ultrasonics Sonochemistry .2019

17. 2019 Cheng KW,Hsieh CM,Chen HW,Chi PC,Yang DP,Chan SH. Determination of synthetic cathinone "α-PVP" and its metabolite in urine using solid phase extraction and gas chromatography-mass spectrometry . Rapid Communications in Mass Spectrometry .2019 ;(9)

18. 2018 Chang CE,Hsieh CM,Chen LC,Su CY,Liu DZ,Jhan HJ, Ho HO, Sheu, MT. Novel application of pluronic lecithin organogels (PLOs) for local delivery of synergistic combination of docetaxel and cisplatin to improve therapeutic efficacy against ovarian cancer . Drug Deliv .2018 ;(25):632-643

19. 2018 Jaiprasart P,Yeung BZ,Lu Z,Wientjes MG,Cui M,Hsieh CM, Woo S, Au JL. Quantitative contributions of processes by which polyanion drugs reduce intracellular bioavailability and transfection efficiency of cationic siRNA lipoplex. . J Control Release .2018 ;(270):101-113

20. 2018 Chang Chia-En ,Hsieh Chien-Ming ,Huang Sheng-Chin ,Su Chia-Yu ,Sheu Ming-Thau . Lecithin-Stabilized Polymeric Micelles (LsbPMs) for Delivering Quercetin: Pharmacokinetic Studies and Therapeutic Effects of Quercetin Alone and in Combination with Doxorubicin . Scientific Reports .2018 ;(8):17640-17640

21. 2017 Hsieh Chien Ming ,Warisnoicharoen Warangkana ,Patel Raju K. ,Kianfar Farnoosh ,Lawrence M. Jayne . Oil-in-water microemulsions stabilized by 3-(N,N- dimethylalkylammonio)propanesulfonate surfactants of varying alkyl chain length: Solubilisation of testos-terone propionate . International Journal of Pharmaceutics .2017 ;(525):1-4

22. 2016 Peng Po Chun ,Hsieh Chien Ming ,Chen Chueh Pin ,Tsai Tsuimin ,Chen Chin Tin . Assessment of photodynamic inactivation against periodontal bacteria mediated by a chitosan hydrogel in a 3D gingival model . International Journal of Molecular Sciences .2016 ;(17)

23. 2016 Sheu Ming Thau ,Hsieh Chien Ming ,Chen Ray Neng ,Chou Po Yu ,Ho Hsiu O. . Rapid-Onset Sildenafil Sublingual Drug Delivery Systems: In Vitro Evaluation and In Vivo Pharmacokinetic Studies in Rabbits . Journal of Pharmaceutical Sciences .2016 ;(105):2774-2781

24. 2015 Sheu Ming Thau ,Jhan Hua Jing ,Hsieh Chien Ming ,Wang Chien Ju ,Ho Hsiu O. . Efficacy of antioxidants as a complementary and alternative medicine (CAM) in combination with the chemotherapeutic agent doxorubicin . Integrative Cancer Therapies .2015 ;(14):184-195

25. 2015 Hung Sheng Feng ,Hsieh Chien Ming ,Chen Ying Chen ,Lin Cheng Mao ,Ho Hsiu O. . Formulation and process optimization of multiparticulate pulsatile system delivered by osmotic pressure-activated rupturable membrane . International Journal of Pharmaceutics .2015 ;(480):15-26

26. 2015 Chen Chueh Pin ,Hsieh Chien Ming ,Tsai Tsuimin ,Yang Jen Chang ,Chen Chin Tin . Optimization and evaluation of a chitosan/hydroxypropyl methylcellulose hydrogel containing toluidine blue O for antimicrobial photodynamic inactivation . International Journal of Molecular Sciences .2015 ;(16):20859-20872

27. 2014 Hsieh Chien Ming ,Huang Yen Hao ,Chen Chueh Pin ,Hsieh Bo Chuan ,Tsai Tsuimin . 5-Aminolevulinic acid induced photodynamic inactivation on Staphylococcus aureus and Pseudomonas aeruginosa . Journal of Food and Drug Analysis .2014 ;(22):350-355

28. 2014 Hsieh Chien Ming ,Huang Yu Wen ,Sheu Ming Thau ,Ho Hsiu O. . Biodistribution profiling of the chemical modified hyaluronic acid derivatives used for oral delivery system . International Journal of Biological Macromolecules .2014 ;(64):45-52

29. 2014 Hung Sheng Feng ,Hsieh Chien Ming ,Chen Ying Chen ,Wang Yu Chun ,Ho Hsiu O. . Characterizations of plasticized polymeric film coatings for preparing multiple-unit floating drug delivery systems (muFDDSs) with controlled-release characteristics . PLoS One .2014 ;(9)

30. 2011 Lorenz Christian D. ,Hsieh Chien Ming ,Dreiss Cécile A. ,Lawrence M. Jayne . Molecular dynamics simulations of the interfacial and structural properties of dimethyldodecylamine-N-oxide micelles . Langmuir .2011 ;(27):546-553

31. 2002 Ho Hsiu O. ,Hsieh Chien Ming ,Sheu Ming Thau . Characteristics of codried products of microcrystalline cellulose with saccharides and low-substituted hydroxypropylcellulose . Powder Technology .2002 ;(127):45-55


1. 2022 Bayu Tri Murti,Athika Darumas Putri,Lalu Muhammad Irham,Dyah Aryani Perwitasari,Chien-Ming Hsieh,Po-Kang Yang, Suvardhan Kanchi, Myalowenkosi Sabela. Current trends, achievements, and prospects of smart nanodevices in the global pharma market . Nanomaterials in Diagnostic Tools and Devices .2022

研究計畫

計畫名稱
111 開發複合式三維度大腸直腸癌生物晶片:抗癌藥物於體外腫瘤微環境之療效評估
補助單位
臺北醫學大學

計畫名稱
111 建構定量系統生理基礎藥動模型以評估腸道菌叢對口服藥物代謝影響及協助奈米膠體處方之開發(3/3)
補助單位
國家科學及技術委員會

計畫名稱
110 建構生理基礎藥物動力學模型以協助長效型針劑開發
補助單位
國家科學及技術委員會

計畫名稱
110 開發仿生具蠕動功能之立體腸道晶片,探討腸道細胞對於小分子抗癌藥物的吸收及生理影響
補助單位
臺北醫學大學

計畫名稱
110 建構定量系統生理基礎藥動模型以評估腸道菌叢對口服藥物代謝影響及協助奈米膠體處方之開發(2/3)
補助單位
科技部

計畫名稱
109 高分子混合微胞結合溫度敏感型水膠之雙效釋放劑型開發與應用
補助單位
科技部

計畫名稱
109 建構定量系統生理基礎藥動模型以評估腸道菌叢對口服藥物代謝影響及協助奈米膠體處方之開發(1/3)
補助單位
科技部

計畫名稱
108 建構人類腸壁多層次動力模型以了解發炎性腸道疾病對口服藥物吸收之影響
補助單位
科技部

計畫名稱
107 醇溶玉米蛋白/酪蛋白鈉奈米粒子之複合水凝膠於小干擾RNA基因局部及持續釋放傳遞之製備與特性之研究(3/3)
補助單位
科技部

計畫名稱
106 新聘教師研究補助
補助單位
臺北醫學大學

計畫名稱
106 醇溶玉米蛋白/酪蛋白鈉奈米粒子之複合水凝膠於小干擾RNA基因局部及持續釋放傳遞之製備與特性之研究(2/3)
補助單位
科技部

計畫名稱
105 醇溶玉米蛋白/酪蛋白鈉奈米粒子之複合水凝膠於小干擾RNA基因局部及持續釋放傳遞之製備與特性之研究(1/3)
補助單位
科技部