| 1. |
2023
Wang CH,Chen CY,Wang KH,Kao AP,Chen YJ,Lin PH, Chen M, Wu TY, Cheng JJ, Lee KD*, Chuang KH*.
Comparing the Therapeutic Mechanism and Immune Response of Human and Mouse Mesenchymal Stem Cells in Immunocompetent Mice with Acute Liver Failure
. STEM CELLS Translational Medicine
.2023
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| 2. |
2022
Hsieh YC,Liao JM,Chuang KH,Ho KW,Hong ST,Liu HJ, Huang BC, Chen IJ, Liu YL, Wang JY, Tsai HL, Su YC, Wang YT, Cheng TL.
A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies
. Journal of Nanobiotechnology
.2022
;(20):1-11
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| 3. |
2022
Ganzon JG,Liaw CC,Lin YC,Lin ZH,Wang CH,Chen CY, Chuang KH, Kuo YH.
New ent-kaurene and germacrene derivatives from Mesona procumbens Hemseley and their biological activity
. Natural Product Research
.2022
;(1):1-9
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| 4. |
2022
Cheng WJ,Chuang KH,Lo YJ,Chen M,Chen YJ,Roffler SR, Ho HO, Lin SY, Sheu MT.
Bispecific T-cell engagers non-covalently decorated drug-loaded PEGylated nanocarriers for cancer immunochemotherapy
. Journal of Controlled Release
.2022
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| 5. |
2022
Wu TY,Chen M,Chen IC,Chen YJ,Chen CY,Wang CH, Cheng JJ, Nepali K, Chuang KH, Liou JP.
Rational design of synthetically tractable HDAC6/HSP90 dual inhibitors to destroy immune-suppressive tumor microenvironment
. Journal of Advanced Research
.2022
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| 6. |
2022
Cheng WJ,Lin SY,Chuang KH,Chen M,Ho HO,Chen LC, Hsieh CM*, Sheu MT*.
Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer.
. International Journal of Nanomedicine
.2022
|
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| 7. |
2021
Cheng WJ,Lin SY,Chen M,Chen LC,Ho HO,Chuang KH, Sheu MT.
Active Tumoral/Tumor Environmental Dual-Targeting by Non-Covalently Arming with Trispecific Antibodies or Dual-Bispecific Antibodies on Docetaxel-Loaded mPEGylated Nanocarriers to Enhance Chemotherapeutic Efficacy and Minimize Systemic Toxicity
. International Journal of Nanomedicine
.2021
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| 8. |
2021
Wei PS,Chen YJ,Lin SY,Chuang KH,Sheu MT,Ho HO.
In situ subcutaneously injectable thermosensitive PEG-PLGA diblock and PLGA-PEG-PLGA triblock copolymer composite as sustained delivery of bispecific anti-CD3 scFv T-cell/anti-EGFR Fab Engager (BiTEE)
. Biomaterials
.2021
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| 9. |
2021
Chang TK,Yin TC,Su WC,Tsai HL,Huang CW,Chen YC, Li CC, Chen PJ, Ma CJ, Chuang KH, Cheng TL, Wang JY.
A Pilot Study of Silymarin as Supplementation to Reduce Toxicities in Metastatic Colorectal Cancer Patients Treated With First-Line FOLFIRI Plus Bevacizumab
. Oncology Research
.2021
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| 10. |
2021
Chen M,Sheu MT,Cheng TL,Roffler SR,Lin SY,Chen YJ, Cheng YA, Cheng JJ, Chang HY, Wu TY, Kao AP, Ho YS, Chuang KH.
A Novel Anti-Tumor/Anti-Tumor-Associated Fibroblast/Anti-mPEG Tri-Specific Antibody to Maximize the Efficacy of mPEGylated Nanomedicines against Fibroblast-Rich Solid Tumor
. Biomaterials Science
.2021
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| 11. |
2020
Ojha R,Nepali K,Chen CH,Chuang KH,Wu TY,Lin TE, Hsu KC, Chao MW, Lai MJ, Lin MH, Huang HL, Chang CD, Pan SL, Chen MC, Liou JP.
Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo
. European Journal of Medicinal Chemistry
.2020
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| 12. |
2020
Mehndiratta S,Lin MH,Wu YW,Chen CH,Wu TY,Chuang KH, Chao MW, Chen YY, Pan SL, Chen MC, Liou JP.
N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression.
. European Journal of Medicinal Chemistry
.2020
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| 13. |
2020
Lin TC,Wang KH,Chuang KH,Kao AP,Kuo TC.
Modulation of tumor stem cell characteristics by 17β-estradiol in human mesenchymal stem cells derived from ovarian endometrioma
. Taiwanese Journal of Obstetrics & Gynecology
.2020
;(58):338-344
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| 14. |
2020
Lin TC,Wang KH,Chuang KH,Kao AP,Kuo TC.
Downregulation of gap junctional intercellular communication and connexin 43 expression by bisphenol A in human granulosa cells
. Biotechnology and Applied Biochemistry
.2020
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| 15. |
2020
Cheng YA,Wu TH,Wang YM,Cheng TL,Chen IJ,Lu YC, Chuang KH, Wang KC, Chen CY, Lin RA, Chen HJ, Liao TY, Liu ES, Chen FM.
Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer
. Journal of Nanobiotechnology
.2020
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| 16. |
2019
Chen YJ,Chen M,Cheng TL,Roffler SR,Lin SY,Hsu HL, Wang CH, Chen CY, Kao AP, Cheng JJ, Chuang KH.
Simply Mixing Poly Protein G with Detection Antibodies Enhances the Detection Limit and Sensitivity of Immunoassays
. Analytical Chemistry
.2019
;(91):8310-8317
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| 17. |
2019
Lu YC,Chuang CH,Chuang KH,Chen IJ,Huang BC, Lee WH, Wang HE, Li JJ, Cheng YA, Cheng KW, Wang JY, Hsieh YC, Lin WW, Cheng TL.
Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy
. PLoS Biology
.2019
;(17):e3000286
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| 18. |
2018
Su CY,Chen M,Chen LC,Ho YS,Ho HO,Lin SY, Chuang KH, Sheu MT.
Bispecific antibodies (anti-mPEG/anti-HER2) for active tumor targeting of docetaxel (DTX)-loaded mPEGylated nanocarriers to enhance the chemotherapeutic efficacy of HER2-overexpressing tumors
. Drug Delivery
.2018
;(25):1066-1079
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| 19. |
2018
Lee CJ,Wang CC,Chen M,Chuan KH,Cheng TL,Jian TY, Wang YM, Huang TH, Liao KW, Tzou SC.
Development of an inflammatory tissue-selective chimeric TNF receptor
. Cytokine
.2018
;(113):340-346
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| 20. |
2018
Chen YJ,Chen M,Hsieh YC,Su YC,Wang CH,Cheng CM, Kao AP, Wang KH, Cheng JJ, Chuang KH.
Development of a highly sensitive enzyme-linked immunosorbent assay (ELISA) through use of poly-protein G-expressing cell-based microplates
. Scientific Reports
.2018
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| 21. |
2017
Lin TC,Wang KH,Kao AP,Chuang KH,Kuo TC.
Pueraria mirifica inhibits 17β-estradiol-induced cell proliferation of human endometrial mesenchymal stem cells
. Taiwanese Journal of Obstetrics & Gynecology
.2017
|
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| 22. |
2017
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) promotes EGF receptor signaling of oral squamous cell carcinoma metastasis via the complex N-glycosylation
. Oncogene
.2017
|
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| 23. |
2017
Hsieh YC,Cheng TC,Wang HE,Li JJ,Lin WW,Huang CC, Chuang CH, Wang YT, Wang JY, Roffler SR, Chuang KH, Cheng TL.
Using anti-poly(ethylene glycol) bioparticles for the quantitation of PEGylated nanoparticles
. Scientific Reports
.2017
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| 24. |
2017
Yu-Cheng Su,Pierre-Alain Burnouf,Kuo-Hsiang Chuang,Bing-Mae Chen,Tian-Lu Cheng,Steve R. Roffler.
Conditional internalization of PEGylated nanomedicines by PEG engagers for triple negative breast cancer therapy
. Nature Communications
.2017
|
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| 25. |
2017
Hao WR,Chen M,Chen YJ,Su YC,Cheng CM,Hsueh HY, Kao AP, Hsieh YC, Chang J, Tseng MY, Chuang KH.
Poly-protein G-expressing bacteria enhance the sensitivity of immunoassays
. Scientific Reports
.2017
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| 26. |
2017
Chen M,Cheng KW,Chen YJ,Wang CH,Cheng TC,Chang KC, Kao AP, Chuang KH.
Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe
. Scientific Reports
.2017
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| 27. |
2016
Lin WW,Hsieh YC,Cheng YA,Chuang KH,Huang CC,Chuang CH, Chen IJ, Cheng KW, Lu YC, Cheng TC, Wang YT, Roffler SR, Cheng TL.
Optimization of an Anti-poly(ethylene glycol)(anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules
. Analytical Chemistry
.2016
;(88):12371-12379
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| 28. |
2016
Huang WC,Burnouf PA,Su YC,Chen BM,Chuang KH,Lee CW, Wei PK, Cheng TL, Roffler SR.
Engineering Chimeric Receptors To Investigate the Size- and Rigidity-Dependent Interaction of PEGylated Nanoparticles with Cells
. ACS Nano
.2016
;(10):648-662
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| 29. |
2016
Chen BM,Su YC,Chang CJ,Burnouf PA,Chuang KH,Chen CH, Cheng TL, Chen YT, Wu JY, Roffler SR..
Measurement of pre-existing IgG and IgM antibodies against polyethylene glycol in healthy individuals
. Analytical Chemistry
.2016
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| 30. |
2015
Ta-Chun Cheng,Chu-Hsiang Pan,Chien-Shu Chen,Kuo-Hsiang Chuang,Chih-Hung Chuang,Chien-Chaio Huang, Yu-Yi Chu, Ya-Chun Yang, Pei-Yu Chu, Chien-Han Kao, Tian-Lu Cheng.
Direct coating of culture medium from cells secreting classical swine fever virus E2 antigen on ELISA plates for detection of E2-specific antibodies
. The Veterinary Journal
.2015
;(205):107-109
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| 31. |
2015
Chih-Hung Chuang,Ta-Chun Cheng,Yu-Ling Leu,Kuo-Hsiang Chuang,Shey-Cherng Tzou,Chien-Shu Chen.
Discovery of Akt Kinase Inhibitors through Structure-BasedVirtual Screening and Their Evaluation as Potential Anticancer Agents
. International Journal of Molecular Sciences
.2015
;(16):3202-3212
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| 32. |
2015
Hsin-Yi Tung,Yu-Cheng Su,Bing-Mae Chen,Pierre-Alain Burnouf,Wei-Chiao Huang,Kuo-Hsiang Chuang,Yu-Ting Yan, Tian-Lu Cheng, Steve R. Roffler.
Selective Delivery of PEGylated Compounds to Tumor Cells by Anti-PEG Hybrid Antibodies
. Molecular Cancer Therapeutics
.2015
;(14):1317-1326
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| 33. |
2014
Kao CH,Wang JY,Chuang KH,Chuang CH,Cheng TC,Hsieh YC, Tseng YL, Chen BM, Roffler SR, Cheng TL..
One-step mixing with humanized anti-mPEG bispecific antibody enhances tumor accumulation and therapeutic efficacy of mPEGylated nanoparticles.
. Biomaterials
.2014
|
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| 34. |
2014
Kuo-Hsiang Chuang,Chien-Han Kao,Steve R. Roffler,Ssu-Jung Lu,Ta-Chun Cheng,Yun-Ming Wang, Chih-Hung Chuang, Yuan-Chin Hsieh, Yeng-Tseng Wang, Kuo-Yi Weng, Tian-Lu Cheng.
Development of an Anti-Methoxy Poly(ethylene glycol) (α-mPEG) Cell-Based Capture System to Measure mPEG and mPEGylated Molecules
. Macromolecules
.2014
|
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| 35. |
2014
Ta-Chun Cheng,Kuo-Hsiang Chuang,Steve Roffler,Kai-Wen Cheng,Yu-Lin Leu,Chih-Hung Chuang, Chien-Chaio Huang, Chien-Han Kao, Yuan-Chin Hsieh, Tian-Lu Cheng, Chien-Shu Chen.
Discovery of specific inhibitors for intestinal E coli. ß-glucuronidase through in silico virtual screening
. The Scientific World Journal
.2014
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| 36. |
2014
Su YC,Al-Qaisi TS,Tung HY,Cheng TL,Chuang KH,Chen BM, Roffler SR.
Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies
. mAbs
.2014
;(6):1069-1083
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| 37. |
2014
Chuang KH,Hsieh YC,Chiang IS,Chuang CH,Kao CH,Cheng TC, Wang YT, Lin WW, Chen BM, Roffler SR, Huang MY, Cheng TL.
High-Throughput Sorting of the Highest Producing Cell via a Transiently Protein-Anchored System
. PLoS One
.2014
;(9)
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| 38. |
2013
Ta-Chun Cheng,Kuo-Hsiang Chuang,Michael Chen,Hsin-Ell Wang,Shey-Cherng Tzou,Yu-Cheng Su, Chih-Hung Chuang, Chien-Han Kao, Bing-Mae Chen, Steve R. Roffler, Tian-Lu Cheng.
Sensitivity of PEGylated Interferon Detection by Anti-Polyethylene Glycol (PEG) Antibodies Depends on PEG Length
. bioconjugate chemistry
.2013
;(24):1408-1413
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| 39. |
2012
Cheng TC,Roffler SR,Tzou SC,Chuang KH,Su YC,Chuang CH, Kao CH, Chen CS, Harm IH, Liu KY, Cheng TL, Leu YL.
An Activity-Based Infrared Glucuronide Trapping Probe for Imaging β-Glucuronidase Expression in Deep Tissues
. Journal of the American Chemical Society
.2012
;(134):3103-3110
|
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| 40. |
2012
Chuang CH,Chuang KH,Wang HE,Roffler SR,Shiea JT,Tzou SC, Wu SY, Cheng TC, Kao CH, Cheng CM, Tseng WL, Hou FM, Wang JM, Cheng TL.
In Vivo Positron Emission Topography Imaging of Protease Activity by Hydrophilic-to-Hydrophobic Conversion of a Non-inhibitory Protease Substrate
. Clinical Cancer Research
.2012
;(18):238-247
|
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| 41. |
2012
Kao CH,Cheng CM,Chuang KH,Chuang CH,Tzou SC,Cheng TC, Hsieh YC, Liao KW, Wang YM, Chang LS, Roffler SR, Chen FM, Cheng TL.
A regularly spaced and self-revealing protein ladder for anti-tag Western blot analysis
. Analytical Biochemistry
.2012
;(431)
|
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| 42. |
2012
Cheng TL,Chuang KH,Chen BM,Roffler SR.
Analytical Measurement of PEGylated Molecules
. Bioconjugate Chemistry
.2012
;(23):881-899
|
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| 43. |
2010
Chuang KH,Tzou SC,Cheng TC,Kao CH,Tseng WL,Shiea J, Liao KW, Wang YM, Chang YC, Huang BJ, Wu CJ, Chu PY, Roffler SR, Cheng TL.
Measurement of poly(ethylene glycol) by cell-based anti-poly(ethylene glycol) ELISA
. Analytical Chemistry
.2010
;(82):2355-2362
|
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| 44. |
2010
Chuang KH,Wang HE,Chen FM,Tzou SC,Cheng CM,Chang YC, Tseng WL, Shiea J, Lin SR, Wang JY, Chen BM, Roffler SR, Cheng TL..
Endocytosis of PEGylated agents enhances cancer imaging and anticancer efficacy
. Molecular Cancer Therapeutics
.2010
;(9):1903-1912
|
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| 45. |
2010
Su YC,Chen BM,Chuang KH,Cheng TL,Roffler SR.
Sensitive quantification of PEGylated compounds by second-generation anti-poly(ethylene glycol) monoclonal antibodies
. Bioconjugate Chemistry
.2010
;(21):1264-1270
|
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| 46. |
2010
Chuang KH,Wang HE,Cheng TC,Tzou SC,Tseng WL,Hung WC, Tai MH, Chang TK, Roffler SR, Cheng TL.
Development of an Universal Anti-Polyethylene Glycol Reporter Gene for Noninvasive Imaging of PEGylated Probes
. Journal of Nuclear Medicine
.2010
;(51):933-941
|
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| 47. |
2010
Kuo-Hsiang Chuang,Tian-Lu Cheng.
Noninvasive Imaging of Reporter Gene Expression and Distribution In Vivo
. Fooyin Journal of Health Sciences
.2010
;(2):1-11
|
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| 48. |
2009
Shey-Cherng Tzou,Steve Roffler,Kuo-Hsiang Chuang,Hsin-Pei Ye,Chien-Han Kao,Yu-Cheng Su, Chiu-Min Cheng, Wei-Lung Tseng, Jentaie Shiea, I-Hong Harm, Kai-Wen Cheng.
Micro-PET imaging of beta-glucuronidase activity by the hydrophobic conversion of a glucuronide probe
. Radiology
.2009
;(252):754-762
|
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| 49. |
2009
C-M Cheng,P-Y Chu,K-H Chuang,SR Roffler,C-H Kao,W-L Tseng, J Shiea, W-D Chang, Y-C Su, B-M Chen, Y-M Wang, and T-L Cheng.
Hapten-derivatized nanoparticle targeting and imaging of gene expression by multimodality imaging systems
. Cancer Gene Therapy
.2009
;(16):83-90
|
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| 50. |
2008
C-M Cheng,Y-L Lu,K-H Chuang,W-C Hung,J Shiea,Y-C Su, C-H Kao, B-M Chen, S Roffler, and T-L Cheng.
Tumor-targeting prodrug-activating bacteria for cancer therapy
. Cancer Gene Therapy
.2008
;(15):393-401
|
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| 51. |
2007
Y-C Su,K-H Chuang,Y-M Wang,C-M Cheng,S-R Lin,J-Y Wang, J-J Hwang, B-M Chen, K-C Chen, S Roffler, T-L Cheng.
Gene expression imaging by enzymatic catalysis of a fluorescent probe via membrane-anchored beta-glucuronidase
. Gene Therapy
.2007
;(14):565-574
|
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| 52. |
2006
Kuo-Hsiang Chuang,Chiu-Min Cheng,Steve R. Roffler,Yu-Lin Lu,Shiu-Ru Lin,Jaw-Yuan Wang, Wen-Shyong Tzou, Yu-Cheng Su, Bing-Mae Chen, Tian-Lu Cheng.
Combination cancer therapy by hapten-targeted prodrug-activating enzymes and cytokines
. Bioconjugate Chemistry
.2006
;(17):707-714
|
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| 53. |
2005
Tian-Lu Cheng,Chiu-Min Cheng,Bing-Mae Chen,Der-An Tsao,Kuo-Hsiang Chuang,Sheng-Wen Hsiao, Yi-Hung Lin, and Steve R. Roffler.
Monoclonal antibody-based quantitation of poly(ethylene glycol)-derivatized proteins, liposomes, and nanoparticles
. Bioconjugate Chemistry
.2005
;(16):1225-1231
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