賴奎宏(Lai, Kuei-Hung) 助理教授

Email
kueihunglai@tmu.edu.tw
現   職
中草藥臨床藥物研發博士學位學程 助理教授

學經歷

學 歷

畢業學校與學位[修業時間]
Uppsala University生藥學部 博士
2014/10~2017/05
高雄醫學大學天然藥物研究所 博士
2010/09~2017/06
國立中正大學生命科學系 學士
2006/09~2010/06

本校學術經歷

任職單位與職稱[起迄時間]
中草藥臨床藥物研發博士學位學程助理教授
2021/03/15~
生藥學研究所助理教授
2020/07/01~2021/03/14

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
生藥學研究所助理教授
2021/04/01 ~

其它經歷

任職單位與職稱[起迄時間]
長庚科技大學博士後研究員
2019/02/11~2020/06/30
國立海洋生物博物館博士後研究員
2017/08/01~2018/02/28

專長與研究領域

學門領域
藥學
Pharmacy
中醫藥學
Chinese Medicine
學術專長
天然物化學
天然物化學
生藥學
生藥學

論文著作

清冊下載


1. 2022 Chen, Y.-Y.,Chen, L.-Y.,Chen, P.-J.,El-Shazly, M., Peng, B.-R.,Chen, Y.-C.; Su, C.-H.; Su, J.-H.; Sung, P.-J.; Yen, P.-T.; Wang, L.-S.; Lai, K.-H.. Probing Anti-Leukemic Metabolites from Marine-Derived Streptomyces sp. LY1209 . Metabolites .2022 ;(12):320-320

2. 2022 Su Chun Han,Cheng Yu Chieh,Chang Yu Chia,Kung Ting Hsuan,Chen Yu Li,Lai Kuei Hung,Hsieh Hsi Lung,Chen Chun Yu,Hwang Tsong Long,Yang Yu Liang,Su Chun Han,Cheng Yu Chieh,Chang Yu Chia,Kung Ting Hsuan,Chen Yu Li,Lai Kuei Hung,Hsieh Hsi Lung,Chen Chun Yu,Hwang Tsong Long,Yang Yu Liang. Untargeted LC-MS/MS-Based Multi-Informative Molecular Networking for Targeting the Antiproliferative Ingredients in Tetradium ruticarpum Fruit . Molecules .2022 ;(27)

3. 2022 Vo Thi Thuy Tien,Huynh Thao Duy,Wang Ching Shuen,Lai Kuei Hung,Lin Zih Chan,Lin Wei Ning,Chen Yuh Lien,Peng Tzu Yu,Wu Ho Cheng,Lee I. Ta,Vo Thi Thuy Tien,Huynh Thao Duy,Wang Ching Shuen,Lai Kuei Hung,Lin Zih Chan,Lin Wei Ning,Chen Yuh Lien,Peng Tzu Yu,Wu Ho Cheng,Lee I. Ta. The Potential Implications of Hydrogen Sulfide in Aging and Age-Related Diseases through the Lens of Mitohormesis . Antioxidants .2022 ;(11)

4. 2022 Lai Kuei Hung,Chen Yu Li,Lin Mei Fang,El-Shazly Mohamed,Chang Yu Chia,Chen Po Jen,Su Chun Han,Chiu Yen Chun,Illias Amina M.,Chen Chih Chuan,Chen Lo Yun,Hwang Tsong Long,Lai Kuei Hung,Chen Yu Li,Lin Mei Fang,El-Shazly Mohamed,Chang Yu Chia,Chen Po Jen,Su Chun Han,Chiu Yen Chun,Illias Amina M.,Chen Chih Chuan,Chen Lo Yun,Hwang Tsong Long. Lonicerae Japonicae Flos Attenuates Neutrophilic Inflammation by Inhibiting Oxidative Stress . Antioxidants .2022 ;(11)

5. 2022 Su Chun Han,Cheng Yu Chieh,Lai Kuei Hung,Chang Yu Chia,Sun Chi Hui,Tu Po Wen,Lin Ching Chih,Hwang Tsong Long,Yang Yu Liang,Su Chun Han,Cheng Yu Chieh,Lai Kuei Hung,Chang Yu Chia,Sun Chi Hui,Tu Po Wen,Lin Ching Chih,Hwang Tsong Long,Yang Yu Liang. Exploring the relationship between metabolite composition and the cold/hot properties ascribed in traditional Chinese medicine by mass spectral molecular networking e A pilot study . Journal of Food and Drug Analysis .2022 ;(30):402-416

6. 2022 Wu Ching Fang,Hung Tzu Ting,Su Yu Chieh,Chen Po Jen,Lai Kuei Hung,Wang Chih Chun,Wu Ching Fang,Hung Tzu Ting,Su Yu Chieh,Chen Po Jen,Lai Kuei Hung,Wang Chih Chun. Endoplasmic Reticulum Stress of Oral Squamous Cell Carcinoma Induces Immunosuppression of Neutrophils . Frontiers in Oncology .2022 ;(12)

7. 2022 Cheng Wei Jen,Yang Hsuan Tzu,Chiang Chih Chao,Lai Kuei Hung,Chen Yu Li,Shih Huei Lin,Kuo Jong Jen,Hwang Tsong Long,Lin Chi Chien,Cheng Wei Jen,Yang Hsuan Tzu,Chiang Chih Chao,Lai Kuei Hung,Chen Yu Li,Shih Huei Lin,Kuo Jong Jen,Hwang Tsong Long,Lin Chi Chien. Deer Velvet Antler Extracts Exert Anti-Inflammatory and Anti-Arthritic Effects on Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Distinct Mouse Arthritis . Comparative Medicine East and West .2022 ;(50):1617-1643

8. 2022 Chen Lo Yun,Peng Bo Rong,Lai Guan Yi,Weng Hao Jui,El-Shazly Mohamed,Su Chun Han,Su Jui Hsin,Sung Ping Jyun,Liao Chung Ping,Lai Kuei Hung,Chen Lo Yun,Peng Bo Rong,Lai Guan Yi,Weng Hao Jui,El-Shazly Mohamed,Su Chun Han,Su Jui Hsin,Sung Ping Jyun,Liao Chung Ping,Lai Kuei Hung. Chemometric-Guided Exploration of Marine Anti-Neurofibroma Leads . Frontiers in Marine Science .2022 ;(9)

9. 2022 Hsieh Chia Ching,Wu Yi Ying,Peng Bo Rong,Lai Kuei Hung,Liao Mei Yi,Chung Hsu Ming,Hsieh Chia Ching,Wu Yi Ying,Peng Bo Rong,Lai Kuei Hung,Liao Mei Yi,Chung Hsu Ming. Chemical Constituents of the Formosan Soft Coral Sinularia querciformis . Chemistry of Natural Compounds .2022 ;(58):975-977

10. 2022 Ke Zong You,Chen Jun Wen,Wu Bo Yan,Jhan Yi Yan,Wen Zhi Hong,Kung Te An,Sung Ping Jyun,Chen Jih Jung,Lai Kuei Hung,Chung Hsu Ming,Ke Zong You,Chen Jun Wen,Wu Bo Yan,Jhan Yi Yan,Wen Zhi Hong,Kung Te An,Sung Ping Jyun,Chen Jih Jung,Lai Kuei Hung,Chung Hsu Ming. A new angular naphthopyrone from feather star Comanthus parvicirrus (M{\uller, 1841) . Journal of Molecular Structure .2022 ;(1253)

11. 2022 Wang SH,Chen YS,Lai KH, Lu CK,Chang HS,Wu HC, Yen FL, Chen LY, Lee JC, Yen CH. Prinsepiae Nux Extract Activates NRF2 Activity and Protects UVB-Induced Damage in Keratinocyte . Antioxidants .2022 ;(11):1755

12. 2022 Nguyen NBA,Chen LY,El-Shazly M,Peng BR,Su JH,Wu HC, Lee IT, Lai KH. Towards Sustainable Medicinal Resources through Marine Soft Coral Aquaculture: Insights into the Chemical Diversity and the Biological Potential . Marine Drugs .2022 ;(20):640

13. 2022 Nguyen NBA ,Chen LY,Chen PJ,El-Shazly M,Hwang TL,Su JH, Su CH, Yen PT, Peng BR, Lai KH. MS/MS Molecular Networking Unveils the Chemical Diversity of Biscembra-noid Derivatives, Neutrophilic Inflammatory Mediators from the Cultured Soft Coral Sarcophyton trocheliophorum . International Journal of Molecular Sciences .2022

14. 2021 Lai KH,Peng BR,Hsu YM,El-Shazly M,Du YC,Lu MC, Su JH, Liu YC. The Configuration-Dependent Anti-Leukemic Effect of Manoalide Stereoisomers: Reignite Research Interest in these Sponge-Derived Sesterterpenoids . Bioorganic Chemistry .2021 ;(114)

15. 2021 Lai Kuei Hung,Huang Zheng Hao,El-Shazly Mohamed,Peng Bo Rong,Wei Wen Chi,Su Jui Hsin,Lai Kuei Hung,Huang Zheng Hao,El-Shazly Mohamed,Peng Bo Rong,Wei Wen Chi,Su Jui Hsin. Isomalabaricane Triterpenes from the Marine Sponge Rhabdastrella sp . Marine Drugs .2021 ;(19)

16. 2021 Hu HC,Tsai YH,Chuang YC,Lai KH,Hsu YM,Hwang TL, Lin CC, Fülöp F, Wu YC, Yu SY, Kuo YT, Chang FR. Estrogenic and anti-neutrophilic inflammatory phenanthrenes from Juncus effusus L. . Natural Product Research .2021

17. 2021 Kumar S,Chang YC,Lai KH,Hwang TL. Resveratrol, a Molecule with Anti-Inflammatory and Anti-Cancer Activities: Natural Product to Chemical Synthesis . Current Medicinal Chemistry .2021

18. 2021 Lai KH,Peng BR,Su CH,El-Shazly M,Sun YL,Shih MC, Huang YT, Yen PT, Wang LS, Su JH. Anti-proliferative potential of secondary metabolites from the marine sponge theonella sp.: Moving from correlation toward causation . Metabolites .2021 ;(11)

19. 2021 Lai KH,Chen PJ,Chen CC,Yang SH,El-Shazly M,Chang YC, Wu YH, Wu YH, Wang YH, Hsieh HL, Hwang TL. Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium . Journal of Ethnopharmacology .2021 ;(264)

20. 2021 Peng BR, Lai KH,Lee GH,Yu SS,Duh CY,Su JH, Zheng LG, Hwang TL, Sung PJ. Scalarane-Type Sesterterpenoids from the Marine Sponge Lendenfeldia sp. Alleviate Inflammation in Human Neutrophils . Marine Drugs .2021 ;(19):561

21. 2021 Wu Yi Ying,Hsieh Chia Ching,Li Chia Ying,Chang Wen Huei,Chen Jih Jung,Lai Kuei Hung,Wen Zhi Hong,Chung Hsu Ming,Wu Yi Ying,Hsieh Chia Ching,Li Chia Ying,Chang Wen Huei,Chen Jih Jung,Lai Kuei Hung,Wen Zhi Hong,Chung Hsu Ming. Natural Cembrane Diterpenoids From the Soft Coral Sinularia querciformis . Natural Product Communications .2021 ;(16)

22. 2020 Chen PJ,Kuo LM,Wu YH,Chang YC,Lai KH,Hwang TL. BAY 41-2272 Attenuates CTGF Expression via sGC/cGMP-Independent Pathway in TGFβ1-Activated Hepatic Stellate Cells . Biomedicines .2020

23. 2020 Peng BR,Lai KH,Chang YC,Chen YY,Su JH,Huang YM, Chen PJ, Yu SSF, Duh CY, Sung PJ. Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents . Marine drugs .2020

24. 2020 Chiang CC,Li YR,Lai KH,Cheng WJ,Lin SC,Wang YH, Chen PJ, Yang SH, Lin CC, Hwang TL. Aqueous extract of kan-lu-hsiao-tu-tan ameliorates collagen-induced arthritis in mice by inhibiting oxidative stress and inflammatory responses . Life .2020 ;(10):1-17

25. 2020 Chang YC,Lai KH,Kumar S,Chen PJ,Wu YH,Lai CL, Hsieh HL, Sung PJ, Hwang TL. 1H NMR-based isolation of anti-inflammatory 9,11-secosteroids from the octocoral sinularia leptoclados . Marine Drugs .2020 ;(18)

26. 2020 Chiang CC,Cheng WJ,Lin CY,Lai KH,Ju SC,Lee C, Yang SH, Hwang TL. Kan-Lu-Hsiao-Tu-Tan, a traditional Chinese medicine formula, inhibits human neutrophil activation and ameliorates imiquimod-induced psoriasis-like skin inflammation . Journal of Ethnopharmacology .2020 ;(246)

27. 2020 Peng BR,Lai KH,Chen YY,Su JH,Huang YM,Chen YH, Lu MC, Yu SSF, Duh CY, Sung PJ. Probing anti-proliferative 24-homoscalaranes from a sponge Lendenfeldia sp. . Marine Drugs .2020 ;(18)

28. 2018 Tsai TC,Lai KH,Su JH,Wu YJ,Sheu JH. 7-Acetylsinumaximol b induces apoptosis and autophagy in human gastric carcinoma cells through mitochondria dysfunction and activation of the perk/eif2α/atf4/chop signaling pathway . Marine Drugs .2018 ;(16)

29. 2018 Peng BR,Lu MC,El-Shazly M,Wu SL,Lai KH,Su JH. Aquaculture soft coral lobophytum crassum as a producer of anti-proliferative cembranoids . Marine Drugs .2018 ;(16)

30. 2018 Chen YC,Lu MC,El-Shazly M,Lai KH,Wu TY,Hsu YM, Lee YL, Liu YC. Breaking down Leukemia Walls: Heteronemin, a Sesterterpene Derivative, Induces Apoptosis in Leukemia Molt4 Cells through Oxidative Stress, Mitochondrial Dysfunction and Induction of Talin Expression . Marine Drugs .2018 ;(16)

31. 2018 Xu JH,Lai KH,Su YD,Chang YC,Peng BR,Backlund A, Wen ZH, Sung PJ. Briaviolides k-n, new briarane-type diterpenoids from cultured octocoral briareum violaceum . Marine Drugs .2018 ;(16)

32. 2018 Lee MG,Liu YC,Lee YL,El-Shazly M,Lai KH,Shih SP, Ke SC, Hong MC, Du YC, Yang JC, Sung PJ, Wen ZH, Lu MC. Heteronemin, a marine sesterterpenoid-type metabolite, induces apoptosis in prostate lncap cells via oxidative and er stress combined with the inhibition of topoisomerase II and Hsp90 . Marine Drugs .2018 ;(16)

33. 2018 Wu CF,Lee MG,El-Shazly M,Lai KH,Ke SC,Su CW, Shih SP, Sung PJ, Hong MC, Wen ZH, Lu MC. Isoaaptamine induces T-47D cells apoptosis and autophagy via oxidative stress . Marine Drugs .2018 ;(16)

34. 2017 Korinek M,Tsai YH,El-Shazly M,Lai KH,Backlund A,Wu SF, Lai WC, Wu TY, Chen SL, Wu YC, Cheng YB, Hwang TL, Chen BH, Chang FR. Anti-allergic hydroxy fatty acids from Typhonium blumei explored through ChemGPS-NP . Frontiers in Pharmacology .2017 ;(8)

35. 2017 Lai KH,You WJ,Lin CC,El-Shazly M,Liao ZJ,Su JH. Anti-inflammatory cembranoids from the soft coral lobophytum crassum . Marine Drugs .2017 ;(15)

36. 2016 Lai KH,Liu YC,Su JH,El-Shazly M,Wu CF,Du YC, Hsu YM, Yang JC, Weng MK, Chou CH, Chen GY, Chen YC, Lu MC. Antileukemic Scalarane Sesterterpenoids and Meroditerpenoid from Carteriospongia (Phyllospongia) sp., Induce Apoptosis via Dual Inhibitory Effects on Topoisomerase II and Hsp90 . Scientific Reports .2016 ;(6)

37. 2016 Lai KH,Lu MC,Du YC,El-Shazly M,Wu TY,Hsu YM, Henz A, Yang JC, Backlund A, Chang FR, Wu YC. Cytotoxic Lanostanoids from Poria cocos . Journal of Natural Products .2016 ;(79):2805-2813

38. 2016 Chiu CP,Hwang TL,Chan Y,El-Shazly M,Wu TY,Lo IW, Hsu YM, Lai KH, Hou MF, Yuan SS, Chang FR, Wu YC. Research and development of Cordyceps in Taiwan . Food Science and Human Wellness .2016 ;(5):177-185

39. 2016 Hsu YM,Chang FR,Lo IW,Lai KH,El-Shazly M,Wu TY, Du YC, Hwang TL, Cheng YB, Wu YC. Zoanthamine-Type Alkaloids from the Zoanthid Zoanthus kuroshio Collected in Taiwan and Their Effects on Inflammation . Journal of Natural Products .2016 ;(79):2674-2680

40. 2013 Wu TY,Du YC,Hsu YM,Lu CY,Singab ANB,El-Shazly M, Hwang TL, Lin WY, Lai KH, Lu MC, Tsai YH, Hou MF, Duh TH, Chang FR. New approach to the characterization and quantification of Antrodia cinnamomea benzenoid components utilizing HPLC-PDA, qNMR and HPLC-tandem MS: Comparing the wild fruiting bodies and its artificial cultivated commercial products . Food Research International .2013 ;(51):23-31

41. 2013 Lu MC,El-Shazly M,Wu TY,Du YC,Chang TT,Chen CF, Hsu YM, Lai KH, Chiu CP, Chang FR, Wu YC. Recent research and development of Antrodia cinnamomea . Pharmacology and Therapeutics .2013 ;(139):124-156

研究計畫

計畫名稱
111 應用化學分子網絡策略建立中藥之抗炎代謝組成資料庫(1/3)
補助單位
國家科學及技術委員會

計畫名稱
110 文旦加工副產物之成分及抗高血糖活性
補助單位
行政院農業委員會

計畫名稱
110 以化學分子網絡探索清熱藥之抗炎代謝組成
補助單位
科技部

計畫名稱
109 新聘教師研究補助
補助單位
臺北醫學大學

計畫名稱
109 中藥治療發炎疾病的化學與藥理圖譜研究
補助單位
科技部