邱士娟(Chiu, Shih-Jiuan) 副教授

Email
sjchiu@tmu.edu.tw
現   職
藥物科學學科 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
美國俄亥俄大學藥學院 博士
1999/09~2005/12
國立臺灣大學藥學研究所 碩士
1996/09~1998/06
國立臺灣大學藥學系 學士
1992/09~1996/06

本校學術經歷

任職單位與職稱[起迄時間]
藥物科學學科副教授
2016/08/01~
藥物科學學科助理教授
2012/02/01~2016/07/31
藥學系助理教授
2010/08/01~2012/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
中草藥臨床藥物研發博士學位學程
2013/08/01 ~

其它經歷

任職單位與職稱[起迄時間]
中央研究院助理
1998/07~1999/07

專長與研究領域

學門領域
藥劑
基因遞送與治療
奈米藥物系統
微脂粒, 高分子聚合物
學術專長
細胞培養
奈米粒子製備
微脂粒製備
Western Blot 蛋白質定量分析
PCR
細胞毒性試驗
細胞攝入試驗
螢光顯微鏡及流式細胞儀相關試驗
藥物釋放&溶離試驗
粒徑分析
藥物安定性試驗

論文著作

清冊下載


1. 2021 Chiu CF,Chiu SJ,Bai LY,Feng CH,Hu JL,Lin WY, Huang HY, Weng JR. A macrolide from Streptomyces sp. modulates apoptosis and autophagy through Mcl-1 downregulation in human breast cancer cells . Environmental toxicology .2021

2. 2021 Chou HC,Lo CH,Chang LH,Chiu SJ,Hu TM. Organosilica colloids as nitric oxide carriers: Pharmacokinetics and biocompatibility . Colloids and Surfaces B: Biointerfaces .2021 ;(208):1-11

3. 2020 Huang TY,Chang TC,Chin YT,Pan YS,Chang WJ,Liu FC, Hastuti ED, Chiu SJ, Wang SH, Changou CA, Li ZL, Shih YJ, Cheng RH, Wu Z, Lin HU, Wang K, Whang-Peng J, Mousa SA, Davis PJChen YR, Chu HR, , . NDAT Targets PI3K-Mediated PD-L1 Upregulation to Reduce Proliferation in Gefitinib-Resistant Colorectal Cancer . Cells .2020 ;(9):1830-1847

4. 2019 Weng JR,Bai LY,Chiu SJ,Chiu CF,Lin WY,Hu JL, Shieh TM. Divaricoside exerts antitumor effects, in part, by modulating Mcl-1 in human oral squamous cell carcinoma cells . Computational and Structural Biotechnology Journal .2019 ;(17):151-159

5. 2018 Lin SY,Wang MR,Chiu SJ,Lin CY,Hu TM. S-Nitrosothiols (SNO) as Light-Responsive Molecular Activators for Post-Synthesis Fluorescence Augmentation in Fluorophore-Loaded Nanospheres . Journal of Materials Chemistry B .2018 ;(6):153-164

6. 2018 Su YL,Lin CY,Chiu SJ,Hu TM. Formation of organosilica nanoparticles with dual functional groups and simultaneous payload entrapment . Journal of Microencapsulation .2018 ;(35):381-391

7. 2017 Bai LY,Chiu CF,Chiu SJ,Chu PC,Weng JR. FTY720 Induces Autophagy- Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism . Scientific Reports .2017 ;(7):1-10

8. 2016 Chiu SJ,Lin CY,Chou HC,Hu TM. Silica Ouzo Effect: Amphiphilic Drugs Facilitate Nanoprecipitation of Polycondensed Mercaptosilanes . Langmuir .2016 ;(32):211-220

9. 2016 Bai LY,Chiu CF,Chu PC,Lin WY,Chiu SJ,Weng JR. A triterpenoid from wild bitter gourd inhibits breast cancer cells . Scientific Reports .2016 ;(6): 1-10

10. 2016 Wu CH,Bai LY,Tsai MH,Chu PC,Chiu CF,Chen MY, Chiu SJ, Chiang JH, Weng JR. Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents–A drug repurposing strategy . Scientific Reports .2016 ;(6):1-11

11. 2015 Chang WL,Peng KJ,Hu TM,Chiu SJ,Liu YL. Nitric oxide-releasing S-nitrosothiol-modified silica/chitosan core-shell nanoparticles . Polymer .2015 ;(57):70-76

12. 2015 Chou HC,Chiu SJ,Hu TM. LbL assembly of albumin on nitric oxide-releasing silica . Biomacromolecules .2015 ;(16):2288-2295

13. 2015 Bai LY,Chiu CF,Chiu SJ,Chen YW,Hu JL,Weng JR. Alphitolic acid, an anti-inflammatory triterpene, induces apoptosis and autophagy in oral squamous cell carcinoma cells, in part, through a p53-dependent pathway . Journal of Functional Foods .2015 ;(18):368-378

14. 2015 Wang MR,Chiu SJ,Chou HC,Hu TM. An efficient S-NO-polysilsesquioxane nano-platform for the co-delivery of nitric oxide and an anticancer drug. . Chemical Communications .2015 ;(51):15649-15652

15. 2015 Lee YY,Li HY,Chiu SJ,Liang WL,Yeh PL,Liu YL. Redox Reaction Mediated Direct Synthesis of Hierarchical Flower-Like CuO Spheres Anchored on Electrospun Poly(vinylidene difluoride) Fiber Surfaces at Low Temperatures . RSC Advances .2015 ;(5):100228-100234

16. 2014 Chou HC,Chiu SJ,Liu YL,Hu TM. Direct Formation of S-Nitroso Silica Nanoparticles from a Single Silica Source . Langmuir .2014 ;(30):812-822

17. 2014 Chiu SJ,Wang SY,Chou HC,Liu YL,Hu TM. Versatile synthesis of thiol- and amine-bifunctionalized silica nanoparticles based on the ouzo effect . Langmuir .2014 ;(30):7676-7686

18. 2014 Hu TM,Chiu SJ,Hsu YM. Nitroxidative chemistry interferes with fluorescent probe chemistry: implications for nitric oxide detection using 2,3-diaminonaphthalene . Biochemical and Biophysical Research Communications .2014 ;(451):196-201

19. 2013 Weng JR,Bai LY,Chiu CF,Hu JL,Chiu SJ,Wu CY. Cucurbitane Triterpenoid from Momordica charantia Induces Apoptosis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-ActivatedReceptor 𝛾 Activation . Evidence-Based Complementary and Alternative Medicine .2013 ;(2013)

20. 2012 Chang SC,Chiu SJ,Hsu CY,Chang Y,Liu YL. White-light fluorescent nanoparticles from self-assembly of rhodamine B-anchored amphiphilic poly(poly(ethylene glycol)methacrylate)-b-poly (glycidyl methacrylate) block copolymer . Polymer .2012 ;(53):4399-4406

21. 2012 Ho SC,Chiu SJ,Hu TM. Comparative kinetics of thiol oxidation in two distinct free-radical generating systems: SIN-1 versus AAPH . Free Radical Research .2012 ;(46):1190-1200

22. 2012 Chen SH,Chiu SJ,Hu TM. Superoxide Dismutase as a Novel Macromolecular Nitric Oxide Carrier: Preparation and Characterization . International Journal of Molecular Sciences .2012 ;(13):13985-14001

23. 2011 Hu CC,Liao JH,Hsu KY,Lin IL,Tsai MH,Wu WH, Wei TT, Huang YS, Chiu SJ, Chen HY, Wu SH, Wu TH. Role of Pirenoxine in the Effects of Catalin on in vitro Ultraviolet-induced Lens Protein Turbidity and Selenite-induced Cataractogenesis in vivo . Molecular Vision .2011 ;(17):1862-1870

24. 2009 Teh-Min Hu,Shih-Jiuan Chiu. Prediction of Human Drug-Clearance Using a Single-Species, Fixed-Exponent Allometric Approach . Journal of Medical Sciences .2009 ;(29):331-339

25. 2006 Chiu SJ,Liu S,Perrotti D,Marcucci G,Lee RJ. Efficient delivery of a Bcl2-specific antisense oligodeoxyribonucleotide (G3139) via transferrin receptor targeted liposome . Journal of controlled release .2006 ;(112):199-207

26. 2006 Chiu SJ,Marcucci G,Lee RJ. Efficient delivery of an antisense oligodeoxyribonucleotide formulated in folate receptor-targeted liposomes . Anticancer Research .2006 ;(26):1049-1056

27. 2006 Zhang ZY,Ugwu S,Zhang A,Ahmad MU,Ahmad Y,Chiu SJ, Lee RJ. A novel cationic cardiolipin analogue for gene delivery . Pharmazie .2006 ;(2006):10-14

28. 2004 Chiu SJ,Ueno NT,Lee RJ. Tumor-targeted gene delivery via anti-HER2 antibody (trastuzumab, Herceptin®,) conjugated polyethylenimine . Journal of controlled release .2004 ;(97):357-369

29. 2001 Chiu SJ,Chen RRL,Chen PF,Lin WJ. In vitro modified release of acyclovir from ethyl cellulose microspheres . Journal of Miroencapsulation .2001 ;(18):559-565


1. 2018 Chiu SJ,Sagala RJ. Development of antibiotics-loaded silica nanoparticles . Controlled Release Asia Meeting, Singapore .2018

2. 2016 Lin CY,Chiu SJ. Multifunctional nanoparticles for cancer therapy . Annual Pharmaceutical Society of ROC .2016

3. 2015 Chiu SJ,Lin CY,Chou HC,Hu TM. Facilitated Nanoprecipitation of Polycondensed Mercaptosilane by Amphiphilic Drugs (Drug-induced Silica Ouzo Effect): Particle Formation, Stabilization, Drug Release and Quantitative Structure-Activity Relationship . European Nanomedicine Meeting 2015 .2015

4. 2015 Hu TM,Wang MR,Chiu SJ,Chou HC. S-NO-polysilsesquioxane nanoprecipitation as an efficient approach to prepare nano drug delivery systems for the codelivery of nitric oxide and theranostics . European Nanomedicine Meeting 2015 .2015

5. 2013 Chiu SJ,Lee YC. Preparation of Chemotherapy Agents and Antisense Oligonucleotides-Loaded Solid Lipid Nanoparticles . Annual Pharmaceutical Society of ROC .2013

6. 2012 Chen WJ,Hu TM,Chiu SJ. Differential growth-modulating activities of nitric oxide donors in hematological cancer cells: bell-shaped effects are dependent on types of cells and donors . Annual Pharmaceutical Society of ROC .2012

7. 2012 Wang SY,Chiu SJ,Hu TM. A Facile Method to Prepare Thiol- and Amine-Bifunctionalized Silica Spheres Using Hybrid Silica Materials . Annual Pharmaceutical Society of ROC .2012

8. 2012 Tsai LH,Chiu SJ. Preparation of Human Serum Albumin Nanoparticles as a Delivery Agent of Antisense Oligonucleotides . Annual Pharmaceutical Society of ROC .2012

9. 2010 He JT,Sun CH,Chen ZB,Chiu SJ. Using Desferrioxamine to Enhance Transferrin Receptor-Targeted Antisense Oilgonucleotide Delivery . Annual Pharmaceutical Society of ROC .2010

10. 2010 Cheng HY,Chen ZB,Sun CH,Chiu SJ. Using liposomal antisense oligonucleotide to sensitize paclitaxel or doxorubicin in cancer cell lines . Annual Pharmaceutical Society of ROC .2010

11. 2009 Shih-Jiuan Chiu,Yun-Jen Chan,Jung-Ying Chen. Transferrin receptor as a target for antisense oligonucleotide delivery . AAPS National Biotechnology Conference .2009

12. 2009 Hang-Yu Cheng,Jyun-Tsang He,Jung-Ying Chen,Zhong-Bo Chen,Chen-Hung Sun,Shih-Jiuan Chiu. Transferrin-targeted liposomes for antisense delivery . Annual Pharmaceutical Society of Republic of China .2009

13. 2008 Yun-Jen Chan,Jung-Ying Chen,Shih-Jiuan Chiu. Study of polyethylenimine-based antisense oligonucleotide delivery system . Annual Pharmaceutical Society of Republic of China .2008

14. 2005 Chiu SJ,Marcucci G,Lee RJ. Folate receptor targeted lipid nanoparticles for G3139 antisense delivery . 2005 AAPS meeting .2005

15. 2005 Chiu SJ,Marcucci G,Lee RJ. Synergistic effect of transferrin and iron chelator (desferrioxamine) on targeted delivery of siRNAs . 2005 AAPS meeting .2005

16. 2005 Hu TM,Chiu SJ,Hayton WL. Extrapolating human drug clearance from a single animal species using the allometric principle with a fixed scaling exponent . 2005 AAPS meeting .2005

17. 2003 Chiu SJ,Lee RJ. HER2 receptor as a target for non-viral gene delivery . .2003

18. 1998 Chiu SJ,Chen RRL. Factorial experiment based preparation of acyclovir-loaded ethyl cellulose microspheres . Annual Pharmaceutical Society of Republic of China .1998


1. 2005 Chiu SJ,Lee RJ. Targeted gene delivery via the folate receptor in Polymeric Gene Delivery: Principles and Applications . .2005

研究計畫

計畫名稱
110 多功能奈米載體攜帶化療藥物併用HDAC抑制劑於三陰性乳癌之應用
補助單位
科技部

計畫名稱
108 GNTBM-EC劑型與GNTBM-PC之開發研究計畫
補助單位
華上生技醫藥股份有限公司

計畫名稱
108 開發多功能奈米載體用於三陰性乳癌之化療藥物之遞送
補助單位
科技部

計畫名稱
106 GNTBM-01劑型之開發
補助單位
華上生技醫藥股份有限公司

計畫名稱
104 多功能奈米粒子之研發及其於癌症治療作為藥物傳輸系統之應用
補助單位
科技部

計畫名稱
102 利用人類血清白蛋白作為反譯寡核苷酸及化療藥物載體之研究
補助單位
學校

計畫名稱
101 研發利用Her2受體為導向來同步運送反義寡核酸及化療藥物之微脂粒系統
補助單位
行政院國家科學委員會

計畫名稱
100 研發利用Her2受體為導向來同步運送反義寡核酸及化療藥物之微脂粒系統
補助單位
行政院國家科學委員會

計畫名稱
99 研發利用Her2受體為導向來同步運送反義寡核苷酸及化療藥物之微脂粒系統
補助單位
行政院國家科學委員會

計畫名稱
98 利用運鐵蛋白導向之微脂粒奈米載體系統對白血病細胞進行siRNA之傳遞
補助單位
行政院國家科學委員會

計畫名稱
97 利用運鐵蛋白導向之微脂粒奈米載體系統對白血病細胞進行siRNA之傳遞
補助單位
行政院國家科學委員會

計畫名稱
96 利用運鐵蛋白導向之微脂粒奈米載體系統對白血病細胞進行siRNA之傳遞(1-3)
補助單位
行政院國家科學委員會

計畫名稱
95 利用運鐵蛋白導向之微脂粒奈米載體系統對白血病細胞進行siRNA之傳遞
補助單位
臺北醫學大學新聘教師計畫