韓嘉莉(Han, Chia-Li) 副教授

Email
was@tmu.edu.tw
現   職
臨床基因體學暨蛋白質體學碩士學位學程 副教授

學經歷

學 歷

畢業學校與學位[修業時間]
臺灣師範大學化學所 博士
2002/08~2008/06
東海大學化學系 學士
1998/08~2002/06

本校學術經歷

任職單位與職稱[起迄時間]
臨床基因體學暨蛋白質體學碩士學位學程副教授
2021/08/01~
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程副教授
2021/02/01~2021/07/31
(舊)臨床藥物基因體學暨蛋白質體學碩士學位學程助理教授
2014/08/06~2021/01/31

本校兼職教學行政經歷

服務單位與職稱[起迄時間]
藥物科學學科助理教授
2019/11/01 ~
生技醫療產業研發博士學位學程助理教授
2017/06/01 ~
中草藥臨床藥物研發博士學位學程助理教授
2016/02/01 ~

其它經歷

任職單位與職稱[起迄時間]
中央研究院博士後研究員
2008/08~2014/08

專長與研究領域

學門領域
學術專長
蛋白質體學
蛋白質體學
蛋白質體學
蛋白質體學
質譜分析
mass spectrometry
生化與生醫分析
bioanalysis

論文著作

清冊下載


1. 2021 Chen XY,Feng PH,Han CL,Jheng YT,Wu CD,Chou HC, Chen YY, Wu SM, Lee KY, Kou HP, Chung KF, Hsiao TC, Chen KY, Ho SC, Chang TY, Chuang HC. Alveolar epithelial inter-alpha-trypsin inhibitor heavy chain 4 deficiency associated with senescence-regulated apoptosis by air pollution . Environmental Pollution .2021 ;(278):116863

2. 2021 Han CL,Chen XR,Lan Albert,Hsu YL,Wu PS,Hung PF, Hung CL, Pan SH. N-glycosylated GPNMB ligand independently activates mutated EGFR signaling and promotes metastasis in NSCLC . Cancer Sci. .2021 ;(112):1911-1923

3. 2021 Jheng YT,Putri D. U.,Chuang HC,Lee KY,Chou HC,Wang SY, Han CL. Prolonged Exposure to Traffic-Related Particulate Matter and Gaseous Pollutants Implicate Distinct Molecular Mechanisms of Lung Injury in Rats . Particle and Fibre Toxicology .2021 ;(18):24

4. 2021 Shih HJ,Chang CY,Huang IT,Tsai PS,Han CL,Huang CJ. Testicular torsion–detorsion causes dysfunction of mitochondrial oxidative phosphorylation . Andrology .2021 ;(9):1902-1910

5. 2021 Chen TT,Wu SM,Chen KY,Tseng CH,Ho SC,Chuang HC, Feng PH, Liu WT, Han CL, Huang WC, Yeh YK, Lee KY. Suppressor of variegation 3-9 homologue 1 impairment and neutrophil-skewed systemic inflammation are associated with comorbidities in COPD . BMC Pulm Med .2021 ;(21):276

6. 2021 Chang JW,Lee YL,Laiman V,Han CL,Jheng YT,Lee KY, Yeh CT, Kuo HP, Chung KF, Heriyanto DS, Hsiao TC, Wu SM, Ho SC, Chuang KJ, Chuang HC*. Air pollution-regulated E-cadherin mediates contact inhibition of proliferation via the Hippo signaling pathways in emphysema . Chemico-Biological Interactions .2021 ;(351):109763

7. 2020 Chen YJ,Roumeliotis TI,Chang YH,Chen CT,Han CL,Lin MH, Chen HW, Chang GC, Chang YL, Wu CT, Lin MW, Hsieh MS, Wang YT, Chen YR, Ionassen I, Ghavidel FZ, Lin ZS, Lin KT, Chen CW, Sheu PY, Hung CT, Huang KC, Yang HC, Lin PY, Yen TC, Lin YW, Jen-Hung Wang JH, Raghav L, Lin CY, Chen YS, Wu PS, Lai CT, Weng SH, Su KY, Chang WH, Tsai PY, Robles AI, Rodriguez H, Hsiao YJ, Chang WH, Sung TY*, Chen JS*, Yu SL*, Choudhary JS*, Chen HY*, Yang PC*, Chen YJ*. Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression . Cell .2020 ;(182):226-244

8. 2020 Han CL,Sheng TC,Wang SY,Chen YH,Kang JH. Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women . Scientific Reports .2020 ;(10):12347

9. 2019 Chien CW,Lo YS,Wu HY,Hsuan Y,Lin CK,Chen YJ, Lin W, Han CL. Transcriptomic and Proteomic Profiling of Human Mesenchymal Stem Cell Derived from Umbilical Cord in the Study of Preterm Birth . Proteomics Clin Appl. .2019

10. 2019 Putri DU,Chiumia FK,Jheng YT,Han CL. The Role of Proteomics for Dissecting Aberrant Molecular Signaling Pathways upon Egfr-Tki Treatments in Non-Small Cell Lung Cancer . Proteomics Bioinformatics Curr Res .2019 ;(1):4-16

11. 2018 Putri DU,Feng PH,Hsu YH,Lee KY,Jiang FW,Kuo LW, Chen YJ, Han CL. Chemotherapy Immunophenoprofiles in Non-small-cell Lung Cancer by Personalized Membrane Proteomics . Proteomics Clin. Appl. .2018 ;(12):x-x

12. 2018 Chang CW,Chen YS,Tsay YG,Han CL,Chen YJ,Yang CC, Hung KF, Lin CH, Huang TY, Kao SY, Lee TC, Lo JF. ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells . Cell Death Dis. .2018 ;(9):194-207

13. 2018 Feng PH,Yu CT,Chen KY,Luo CS,Wu SM,Liu CY, Kuo LW, Chan YF, Chen TT, Chang CC, Lee CN, Chuang HC, Lin CF, Han CL, Lee WH, Lee KY*. S100A9+ MDSC and TAM-mediated EGFR-TKI resistance in lung adenocarcinoma: the role of RELB . Oncotarget .2018 ;(9):7631-7643

14. 2018 Feng PH,Chen KY,Huang YC,Luo CS,Wu SM,Chen TT, Lee CN, Yeh CT, Chuang HC, Han CL, Lin CF, Lee WH, Kuo CH, Lee KY*. Bevacizumab Reduces S100A9+ MDSC Linked to Intracranial Control in Patients with EGFR Mutant Lung Adenocarcinoma . J Thorac Oncol. .2018 ;(x):x-x

15. 2018 Wu HY,Kuo PC,Wang YT,Lin HT,Roe AD,Wang BY, Han CL, Hyman BT, Chen YJ, Tai HC. β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals . J Neuropathol Exp Neurol. .2018 ;(77):814-826

16. 2018 Weldemariam MM,Han CL,Shekari F,Kitata RB,Chuang CY,Hsu WT, Kuo HC, Choong WK, Sung TY, He FC, Chung MCM, Salekdeh GH, Chen YJ. Subcellular Proteome Landscape of Human Embryonic Stem Cells Revealed Missing Membrane Proteins . J. Proteome Res. .2018

17. 2018 Shekari F,Han CL,Lee J,Mirzaei M,Gupta V,Haynes PA, Lee B, Baharvand H, Chen YJ, Hosseini Salekdeh G. Surface markers of human embryonic stem cells: a meta analysis of membrane proteomics reports. . Expert Rev Proteomics .2018

18. 2018 Chen WT,Hsu WT,Yen MH,Changou CA,Han CL,Chen YJ, Cheng JY, Chang TH, KS Lee, Ho HC. Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization . Biomaterials .2018 ;(190-191):1-10

19. 2017 Shekari F ,Hossein N,Larijani MR ,Han CL,Baharvand H ,Chen YJ, Salekdeh GH. Proteome analysis of human embryonic stem cells organelles . Journal of Proteomics .2017 ;(162):108-118

20. 2017 Hung CL,Pan SH,Han CL,Chang CW,Hsu YL,Su CH, Shih SC, Lai YJ, Chiang Chiau JS, Yeh HI, Liu CY, Lee HC, Lam CSP. Membrane Proteomics of Impaired Energetics and Cytoskeletal Disorganization in Elderly Diet-Induced Diabetic . J. Proteome Res. .2017 ;(16):3504-3513

21. 2017 Tsai MT,Chen YJ,Chen CY,Tsai MH,Han CL,Chen YJ, Mersmann HJ, Ding ST. Identification of Potential Plasma Biomarkers for Nonalcoholic Fatty Liver Disease by Integrating Transcriptomics and Proteomics in Laying Hens . J. Nutr. .2017 ;(147):293-303

22. 2016 Chia-Ling Chen,Yueh-Ying Wu,Chiou-Feng Lin,Chih-Feng Kuo,Chia-Li Han,Shuying Wang, Woei-Jer Chuang, Chiu-Yueh Chen, Jiunn-Jong Wu, Pei-Jane Tsai, Ching-Chuan Liu & Yee-S. Streptococcal pyrogenic exotoxin B inhibits apoptotic cell clearance by macrophages through protein S cleavage . Scientific Reports .2016 ;(6):1-14

23. 2015 Che TF,Lin CW,Wu YY,Chen YJ,Han CL,Chang YL, Wu CT, Hsiao TH, Hong TM, Yang PC. Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC . Oncotarget .2015 ;(6):37349-37366

24. 2014 Chang CW,Chen YS,Chou SH,Han CL,Chen YJ,Yang CC, Huang CY, Lo JF. Distinct Subpopulations of Head and Neck Cancer Cells with Different Levels of Intracellular Reactive Oxygen Species Exhibit Diverse Stemness . Cancer Res. .2014 ;(74):6291-6305

25. 2014 Fathia A,Hatamic M,Vakiliana H,Han CL,Chen YJ,Baharvand H, Salekdeh GH. Quantitative proteomics analysis highlights the role of redox hemostasis and energy metabolism in human embryonic stem cell differentiation to neural cells . J Proteomics .2014 ;(101):1-14

26. 2013 Chiang SC,Han CL,Yu KH,Chen YJ,Wu KP. Prioritization of cancer marker candidates based on the immunohistochemistry staining images deposited in the human protein atlas . PLoS ONE .2013 ;(8):e81079

27. 2013 Huang TK,Han CL,Lin SI,Chen YJ,Tsai YC,Chen YR, Chen JW, Lin WY, Chen PM, Liu TY, Chen YS, Sun CM, Chiou TJ. Identification of Downstream Components of Ubiquitin-Conjugating Enzyme PHOSPHATE2 by Quantitative Membrane Proteomics in Arabidopsis Roots . Plant Cell .2013 ;(25):4044-4060

28. 2013 Ho H,Lee K,Fu YJ,Shih HT,Tseng CY,Chung CC, Han CL, Chen YJ. An iTRAQ Proteomic Study Reveals an Association between Diet-Induced Enhanced Fatty Acid Metabolism and the Development of Glucose Intolerance in Prediabetic Mice . J. Proteome Res. .2013 ;(12):1120-1133

29. 2013 Lu YW,Chien CW,Lin PC,Huang LD,Chen CY,Wu SW, Han CL, Khoo KH, Lin CC, Chen YJ. BAD-Lectins: Boronic Acid-Decorated Lectins with Enhanced Binding Affinity for the Selective Enrichment of Glycoproteins . Anal. Chem. .2013 ;(85):8268-8276

30. 2013 Lin PC,Yu CC,Wu HT,Lu YW,Han CL,Su AK, Chen YJ, Lin CC. A chemically functionalized magnetic nanoplatform for rapid and specific biomolecular recognition and separation . Biomacromolecules .2013 ;(14):160-168

31. 2011 Han CL,Chen JS,Chan EC,Wu CP,Yu KH,Chen KT, Tsou CC, Tsai CF, Chien CW, Kuo YB, Lin PY, Yu JS, Hsueh C, Chen MC, Chan CC, Chang YS, Che. An Informatics-assisted Label-free Approach for Personalized Tissue Membrane Proteomics: Case Study on Colorectal Cancer . Mol. Cell. Proteomics .2011 ;(10):1-15

32. 2011 Fan CW,Chan CC,Chen KT,Twu J,Huang YS,Han CL, Chen YJ, Yu JS, Chang YS, Kuo YB, Chan EC. Identification of SEC61β and its autoantibody as biomarkers for colorectal cancer . Clin Chim Acta. .2011 ;(412):887-893

33. 2010 Chen JS,Chen KT,Fan CW,Han CL,Chen YJ,Yu JS, Chang YS, Chien cW, Wu CP, Hung RP, Chan EC. Comparison of Membrane Fraction Proteomic Profiles of Normal and Cancerous Human Colorectal Tissues with Gel-assisted Digestion and iTRAQ Labeling Mass Spectrometry . FEBS J .2010 ;(277):3028-3038

34. 2010 Lin SL,Chien CW,Han CL,Chen SW,Kao SH,Chen YJ, Liao F. Temporal Proteomics Profiling of Lipid Rafts in CCR6-activated T Cells Reveals the Integration of Actin Cytoskeleton Dynamics . J. Proteome Res. .2010 ;(9):283-297

研究計畫

計畫名稱
110 結合深度學習及數據非依賴採集質譜法以偵測膜蛋白體突變與癌症新生抗原(1/3)
補助單位
科技部

計畫名稱
109 建立可偵測多重膜蛋白突變之蛋白基因體平台(延續計畫)
補助單位
科技部

計畫名稱
108 建立可偵測多重膜蛋白突變之蛋白基因體平台
補助單位
科技部

計畫名稱
107 臨床藥物基因體學暨蛋白質體學碩士學位學程韓嘉莉助理教授擬於108年7月赴葡萄牙Caparica參加VI International Caparica Conference on Analytical Proteomics 2019
補助單位

計畫名稱
107 建立質譜定量分析策略以應用於癌症特定突變蛋白質之腫瘤蛋白質基因體學研究(第二至三年)(2/2)
補助單位
科技部

計畫名稱
106 韓嘉莉助理教授擬於106年9月赴愛爾蘭都伯林參加HUPO 16th Annual World Congress (HUPO 2017)
補助單位
科技部

計畫名稱
106 建立質譜定量分析策略以應用於癌症特定突變蛋白質之腫瘤蛋白質基因體學研究(第二至三年)(1/2)
補助單位
科技部

計畫名稱
105 建立質譜定量分析策略以應用於癌症特定突變蛋白質之腫瘤蛋白質基因體學研究
補助單位

計畫名稱
104 以蛋白體及磷酸化蛋白體分析探討化療藥物pemetrexed在非小細胞肺癌中引發之訊息傳遞網絡
補助單位
科技部

計畫名稱
103 以深度蛋白體分析探討非小細胞肺癌病人骨髓源生抑制性細胞與肺癌細胞在藥物治療下之交互作用機制
補助單位
衛生福利部雙和醫院(委託臺北醫學大學興建經營)

計畫名稱
103 TMU103-AE1-B14
補助單位
臺北醫學大學新聘教師計畫

計畫名稱
103 (103)新聘教師研究補助-韓嘉莉教師
補助單位
臺北醫學大學